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This book aims to examine all immunohistochemical and molecular pathological biomarkers that can be useful and effective in patient diagnosis, prognosis and treatment decision, especially when faced with a carcinoma of unknown primary. For this purpose, epithelial malignancies of all systems and related biomarkers are examined one by one, and to look at the subject through the metastatic regions window, biomarkers that can be used to determine the primary focus for carcinomas seen in the areas most frequently metastasized are emphasized. With this bi-directional perspective, the reader is able to find biomarkers of any type of carcinoma on a system basis, as well as access to which biomarkers can be used when faced with a metastatic carcinoma. The importance of biomarkers in patient follow-up and treatment is also conveyed through the clinician's eye, and so biomarkers are handled with a holistic approach in all aspects. This book primarily targets pathologists, as well as clinicians (oncologists and surgeons) who manage cancer patients.
Pages i-x
Definition of “Tissue-Based Biomarker,” its Place in Medicine, and Molecular Pathology
Ozgul Sagol, Sulen Sarioglu
Pages 1-19
The Concept and Mechanisms of Metastasis
Sumeyye Ekmekci, Safiye Aktas
Pages 21-45
Sumeyye Ekmekci, Banu Lebe
Pages 47-66
Biomarkers in Head and Neck Carcinomas
M. Hasan Toper, Sulen Sarioglu, Alena Skálová
Pages 67-98
Biomarkers in Pulmonary Carcinomas
Betul Gundogdu, Duygu Gurel, Emine Cagnur Ulukus
Pages 99-128
Biomarkers in Endocrine Organ Carcinomas
Yasemin Sahin, Merih Guray Durak, Ozgur Mete
Pages 129-164
Biomarkers in Gastrointestinal System Carcinomas
Burcin Pehlivanoglu, S. Mehtat Unlu
Pages 165-199
Biomarkers in Hepatopancreatobiliary Carcinomas
Anil Aysal, Ozgul Sagol
Pages 201-235
Biomarkers in Urinary Tract and Male Genital System Carcinomas
Ibrahim H. Erdogdu, Burcin Tuna, Kutsal Yorukoglu, Rodolfo Montironi
Pages 237-273
Biomarkers in Gynecologic Carcinomas
Canan Kelten Talu, Emine Cagnur Ulukus, Wenxin Zheng
Pages 275-307
Biomarkers in Breast Carcinomas
Yasemin Sahin, Ibrahim H. Erdogdu, Merih Guray Durak, Duygu Gurel, Aysegul A. Sahin
Pages 309-333
Diagnostic Approach According to More Frequent Metastatic Sites: Liver, Lung, Bone, and Lymph Nodes
Anil Aysal, Betul Gundogdu, Burcin Pehlivanoglu, Sumeyye Ekmekci, M. Hasan Toper, Canan Kelten Talu et al.
Pages 335-379
M. Hasan Toper, Canan Kelten Talu, Burcin Pehlivanoglu, Yasemin Sahin, S. Mehtat Unlu, Duygu Gurel et al.
Pages 381-413
Management of the Patients with Carcinoma of Unknown Primary and the Role of Biomarkers
Cihan Ağalar, Gokcen Omeroglu Simsek
Pages 415-431
Treatment Approach to Carcinomas of Unknown Primary
Sinan Unal, Hüseyin Salih Semiz, Ilhan Oztop
Pages 433-441
Pages 443-473
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