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Description
Atlas on the Human Testis: Normal Morphology and Pathology presents histological illustrative material from paraffin and semi-thin sections of the human testis which are routinely used in the assessment of testicular morphology, allowing an early detection of carcinoma in situ and more advanced pathological changes of the testicular parenchyma. The early detection of cancer in situ is based on the careful morphological investigation of the biopsy and immunohistochemistry (IHC). Therefore, this atlas contains detailed descriptions of IHC methods as well as modern molecular biological methods such as DNA microarrays and proteomics and advanced microscopy techniques related to the testicular biopsy.
Adequate evaluation of the testicular biopsy leads to high cure rates of testicular neoplasms which can be used as a basis to successfully treat infertility in men.
Atlas on the Human Testis: Normal Morphology and Pathology is a valuable reference tool which will appeal to andrologists, urologists, pathologists, clinical embryologists, as well as reproductive biology scientists.
Table of Contents
1 “Open” Biopsy of the Testis and Testicular
Sperm Extraction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Ivan Krhen, Andreja Vukasović, and Davor Ježek
2 MicroTESE and Embryo Development . . . . . . . . . . . . . . . . . . . . . 7
Nikica Zaninović and Peter N. Schlegel
3 Histologic Procedures and Testicular Biopsy Freezing . . . . . . . . 23
Andreja Vukasović, Viviana Kozina, and Davor Ježek
4 Early Development of the Human Testis . . . . . . . . . . . . . . . . . . . . 37
Gordana Jurić-Lekić, Marta Himelreich, Marta Lekić,
Ðurđica Grbeša, and Floriana Bulić-Jakuš
5 The Fetal Human Testis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55
Marina Kos and Tanja Leniček
6 The Testis in Childhood Between Birth and Puberty . . . . . . . . . . 69
Ewa Rajpert-De Meyts, Kristian Almstrup, John E. Nielsen,
and Niels E. Skakkebæk
7 Normal Morphology of the Human
Testis and Epididymis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77
Davor Ježek, Viviana Kozina, and Andreja Vukasović
8 Damage of Spermatogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99
Martin Bergmann and Davor Ježek
9 Inflammatory Conditions of the Testis . . . . . . . . . . . . . . . . . . . . . . 113
Hans-Christian Schuppe and Martin Bergmann
10 Cryptorchidism (Undescended Testis) . . . . . . . . . . . . . . . . . . . . . . 123
Ljerka Banek, Viviana Kozina, Iva Marolt,
and Tomislav Banek
11 Klinefelter’s Syndrome . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147
Manuel Nistal and Pilar González-Peramato
12 Testicular Dysgenesis Syndrome and Carcinoma
In Situ Testis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 159
Ewa Rajpert-De Meyts, Kristian Almstrup,
and Niels E. Skakkebæk
13 Tumors of the Testis and Epididymis . . . . . . . . . . . . . . . . . . . . . . . 179
Ivan Damjanov and Gregor Mikuz
14 Congenital Testis Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 233
Manuel Nistal and Pilar González-Peramato
15 Vascular Testis Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 243
Manuel Nistal and Pilar González-Peramato
16 New Approaches to Diagnosing Male Infertility,
Part I: Microarray Analysis of Testicular Biopsy Specimens
from Men with Intact and Impaired Spermatogenesis . . . . . . . . 253
Andrej-Nikolai Spiess and Wolfgang Schulze
17 New Approaches to Diagnosing Male Infertility,
Part II: The Role of Confocal Microscopy
and Three-Dimensional Reconstruction in Visualization
of Reinke’s Crystals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 261
Viviana Kozina and Davor Ježek
18 Disorders of Sex Development . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 265
Manuel Nistal and Pilar González-Peramato
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 281
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