xi
Contents
1 Normal Morphologic and Immunohistochemical Findings and Hyperplasias
1.1 Anatomy and Normal Histology ........................................................................ 2
1.2 Hyperplasias ....................................................................................................... 6
1.3 Normal Immunohistochemistry ......................................................................... 7
2 Congenital Malformations and Abnormalities of Spleen Location
and Histology
2.1 Accessory Spleen ............................................................................................... 12
2.2 Intrapancreatic Spleen ........................................................................................ 13
2.3 Polysplenia ......................................................................................................... 13
2.4 Splenosis ............................................................................................................ 14
2.5 Splenogonadal Fusion ........................................................................................ 14
2.6 Other Findings .................................................................................................... 15
3 Lymphoid Neoplasms
3.1 Splenic Marginal Zone Lymphoma .................................................................... 18
3.2 Chronic Lymphocytic Leukemia ........................................................................ 23
3.3 Lymphoplasmacytic Lymphoma ........................................................................ 26
3.4 Follicular Lymphoma ......................................................................................... 27
3.5 Mantle Cell Lymphoma...................................................................................... 30
3.6 Plasma Cell Myeloma ........................................................................................ 32
3.7 Hairy Cell Leukemia .......................................................................................... 33
3.8 Hairy Cell Leukemia-Variant ............................................................................. 37
3.9 Splenic Diffuse Red Pulp Small B-Cell Lymphoma .......................................... 38
3.10 Prolymphocytic Leukemia ................................................................................. 39
3.11 Lymphoblastic Leukemia/Lymphoma ................................................................ 40
3.12 Hepatosplenic T-cell Lymphoma ....................................................................... 40
3.13 T-cell Large Granular Lymphocytic Leukemia .................................................. 43
3.14 Other T-cell Lymphomas .................................................................................... 46
3.15 Diffuse Large B-cell Lymphomas ...................................................................... 49
3.16 Hodgkin Lymphoma........................................................................................... 55
4 Myeloid and Related Disorders
4.1 Extramedullary Hematopoiesis .......................................................................... 60
4.2 Myeloid Sarcoma/Acute Myeloid Leukemia ..................................................... 61
4.3 Myeloproliferative Neoplasms ........................................................................... 64
4.4 Myelodysplastic Syndrome and Myelodysplastic/
Myeloproliferative Disorders ............................................................................... 69
4.5 Mastocytosis ....................................................................................................... 71
4.6 Histiocytic Sarcoma ........................................................................................... 73
5 Nonhematopoietic Lesions Including Vascular
5.1 Cysts ................................................................................................................... 76
5.2 Hamartoma ......................................................................................................... 78
5.3 Inflammatory Pseudotumor ................................................................................ 83
xii Contents
5.4 Follicular Dendritic Cell Tumor ......................................................................... 84
5.5 Other Stromal Tumors ........................................................................................ 85
5.6 Splenic Artery Aneurysm ................................................................................... 86
5.7 Benign Vascular Lesions .................................................................................... 87
5.8 Littoral Cell Angioma ........................................................................................ 92
5.9 Sclerosing Angiomatoid Nodular Transformation (SANT) ............................... 94
5.10 Vascular Tumors of Indeterminate and Malignant Behavior ............................. 96
5.11 Metastatic Tumors .............................................................................................. 99
Reference .................................................................................................................... 106
6 Reactive and Systemic Conditions
6.1 Rupture and Trauma ........................................................................................... 108
6.2 Infarction and Embolization ............................................................................... 109
6.3 Perisplenitis (Sugar-Coated Spleen)................................................................... 112
6.4 Congestive Splenomegaly .................................................................................. 113
6.5 Red Blood Cell Disorders .................................................................................. 114
6.6 Granulomas ........................................................................................................ 118
6.7 Langerhans Cell Histiocytosis ............................................................................ 119
6.8 Storage Diseases................................................................................................. 120
6.9 Castleman Disease ............................................................................................. 127
6.10 Therapy Effects .................................................................................................. 128
6.11 Other Disorders .................................................................................................. 130
6.12 Hemophagocytic Syndrome ............................................................................... 132
6.13 Autoimmune Disorders ...................................................................................... 133
6.14 Immunodeficiency (Inherited and Acquired) ..................................................... 139
Reference .................................................................................................................... 142
7 Infections
7.1 Bacterial ............................................................................................................. 144
7.2 Mycobacteria ...................................................................................................... 145
7.3 Viruses ................................................................................................................ 147
7.4 Fungi .................................................................................................................. 151
7.5 Parasites and Protozoa ........................................................................................ 155
Reference .................................................................................................................... 156
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 157