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This atlas is designed to be a user-friendly bench-side reference for pathology trainees and general pathologists in handling and interpreting specimens of hepatocellular carcinoma. It provides over 550 high-quality gross and microscopic photos focusing on hepatocellular carcinoma and its mimickers, and demonstrating a full range of various histological variants of hepatocellular carcinoma. Introductory text in each chapter summarises salient clinical associations, pathological features, and molecular alterations of different variants of hepatocellular carcinoma. Differentiation between hepatocellular carcinoma and its mimickers is illustrated through various case studies.
The authors are nationally and internationally recognized hepatopathologists in the Asian-Pacific regions (Hong Kong, Korea, the Philippines, and Singapore), in which the incidence of hepatocellular carcinoma is high.
Dr. Haeryoung Kim is a professor in Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Dr. Wei-Qiang Leow is currently a consultant pathologist at the Department of Anatomical Pathology, Division of Pathology, Singapore General Hospital, Singapore.
Dr. Regina Lo is a clinical associate professor in Department of Pathology, the University of Hong Kong, Hong Kong.
Dr. Paulo Giovanni L. Mendoza is the laboratory department chair, Cardinal Santos Medical Center, Manila, Philippines.
Dr. Anthony Wing-Hung Chan is an honorary clinical associate professor in Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, the Chinese University of Hong Kong, Hong Kong.
Haeryoung Kim, Wei-Qiang Leow, Regina Lo, Paulo Giovanni L. Mendoza, Anthony Wing-Hung Chan
Pages 1-2
Precursor Lesions of Hepatocellular Carcinoma
Haeryoung Kim, Wei-Qiang Leow, Regina Lo, Paulo Giovanni L. Mendoza, Anthony Wing-Hung Chan
Pages 3-25
Gross Morphology of Hepatocellular Carcinoma
Haeryoung Kim, Wei-Qiang Leow, Regina Lo, Paulo Giovanni L. Mendoza, Anthony Wing-Hung Chan
Pages 27-30
General Histopathological Features of Hepatocellular Carcinoma
Haeryoung Kim, Wei-Qiang Leow, Regina Lo, Paulo Giovanni L. Mendoza, Anthony Wing-Hung Chan
Pages 31-46
Fibrolamellar Hepatocellular Carcinoma
Haeryoung Kim, Wei-Qiang Leow, Regina Lo, Paulo Giovanni L. Mendoza, Anthony Wing-Hung Chan
Pages 47-49
Steatohepatitic Hepatocellular Carcinoma
Haeryoung Kim, Wei-Qiang Leow, Regina Lo, Paulo Giovanni L. Mendoza, Anthony Wing-Hung Chan
Pages 51-55
Clear Cell Hepatocellular Carcinoma
Haeryoung Kim, Wei-Qiang Leow, Regina Lo, Paulo Giovanni L. Mendoza, Anthony Wing-Hung Chan
Pages 57-59
Macrotrabecular-Massive Hepatocellular Carcinoma
Haeryoung Kim, Wei-Qiang Leow, Regina Lo, Paulo Giovanni L. Mendoza, Anthony Wing-Hung Chan
Pages 61-64
Scirrhous Hepatocellular Carcinoma
Haeryoung Kim, Wei-Qiang Leow, Regina Lo, Paulo Giovanni L. Mendoza, Anthony Wing-Hung Chan
Pages 65-67
Lymphocyte-Rich Hepatocellular Carcinoma
Haeryoung Kim, Wei-Qiang Leow, Regina Lo, Paulo Giovanni L. Mendoza, Anthony Wing-Hung Chan
Pages 69-75
Other Uncommon Histological Variants of Hepatocellular Carcinoma
Haeryoung Kim, Wei-Qiang Leow, Regina Lo, Paulo Giovanni L. Mendoza, Anthony Wing-Hung Chan
Pages 77-83
Hepatocellular Carcinoma with Cytokeratin 19 Expression
Haeryoung Kim, Wei-Qiang Leow, Regina Lo, Paulo Giovanni L. Mendoza, Anthony Wing-Hung Chan
Pages 85-88
Combined Hepatocellular-Cholangiocarcinoma
Haeryoung Kim, Wei-Qiang Leow, Regina Lo, Paulo Giovanni L. Mendoza, Anthony Wing-Hung Chan
Pages 89-96
Post-treatment Changes of Hepatocellular Carcinoma
Haeryoung Kim, Wei-Qiang Leow, Regina Lo, Paulo Giovanni L. Mendoza, Anthony Wing-Hung Chan
Pages 97-101
Ancillary Tests for Hepatocellular Carcinoma
Haeryoung Kim, Wei-Qiang Leow, Regina Lo, Paulo Giovanni L. Mendoza, Anthony Wing-Hung Chan
Pages 103-144
Tumour Staging for Hepatocellular Carcinoma
Haeryoung Kim, Wei-Qiang Leow, Regina Lo, Paulo Giovanni L. Mendoza, Anthony Wing-Hung Chan
Pages 145-153
Differential Diagnoses of Hepatocellular Carcinoma
Haeryoung Kim, Wei-Qiang Leow, Regina Lo, Paulo Giovanni L. Mendoza, Anthony Wing-Hung Chan
Pages 155-193
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