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Pharmacokinetic Properties
Pages 3-27
This book is a comprehensive resource on psychotropic medications, detailing the latest methods for defining their characteristics, their use in different patient populations, and drug-drug interactions; an important collection of information forclinicians, students, researchers, and members of the pharmaceutical industry alike.
The first section provides the foundational principles of these drugs. Mathematical modeling of parameters that affect their entryto,and exit from, the central nervous system (CNS) compartment are presented on an individual basis and then applied to target populations with specific disease states. Methods and characteristics that inform the transfer of these drugs from the laboratory bench to use in patient care are discussed, including imaging techniques, genetics and physiological barriers, such as the blood-brain barrier. The second section describes the characteristics of specific agents,nominally arranged intodifferent therapeutic categories and with reference crossover use in different disease states. The pharmacologic characteristics of different drug formulations are explored in the context of their ability to improve patient adherence. The third section focuses on drug-drug interactions.Psychotropic medications from different categories are frequently prescribed together,or alongside medications used to treat comorbid conditions, and the information provided is directly relevant to the clinic, as a result.
The clinical application of pharmacokinetics and pharmacodynamics of CNS agents has made significant progress over the past 50 years and new information is reported by numerous publications in psychiatry, neurology, and pharmacology.Our understanding of the interrelationship between these medications, receptors, drug transporters, as well as techniques for measurement and monitoring their interactions,isfrequently updated. However, with information presented on a host of different platforms, and in different formats, obtaining the full picture can be difficult. This title aims to collate this information into a single source that can be easily interpreted and applied towards patient care by the clinical practitioner, and act as a reference for all others who have an interest in psychopharmacological agents.
Pharmacokinetic Properties
Pages 3-27
Pharmacodynamics
Pages 29-48
Positron Emission Tomography (PET) Use in Pharmacology
Pages 49-70
Population Pharmacokinetics
Pages 71-90
Drug Transporters
Pages 91-119
Pharmacogenomics
Pages 121-135
Antipsychotics
Pages 139-175
Mood Stabilizers
Pages 177-203
Antidepressants
Pages 205-245
Clinical Pharmacokinetics and Pharmacodynamics of Anxiolytics and Sedative/Hypnotics
Pages 247-266
Opioid Analgesics
Pages 267-301
Stimulants and Other Non-stimulants for Attention-Deficit/Hyperactivity Disorder (ADHD)
Pages 303-327
Antidementia Drugs
Pages 329-349
Anti-addiction Agents
Pages 351-372
Anesthetic Drugs Pharmacokinetics and Pharmacodynamics
Pages 373-394
Clinically Significant Interactions with Antipsychotics
Pages 397-421
Clinically Significant Interactions with Mood Stabilisers
Pages 423-449
Clinically Significant Interactions with Antidepressants
Pages 451-469
Clinically Significant Interactions with Benzodiazepines
Pages 471-495
Clinical Significant Interactions with Opioid Analgesics
Pages 497-534
Clinically Significant Interactions with Stimulants and Other Non-stimulants for ADHD
Pages 535-549
Clinically Significant Interactions with Cholinesterase Inhibitors and Other Antidementia Agents
Pages 551-563
Clinically Significant Interactions with Anti-addiction Agents
Pages 565-577
Clinically Significant Interactions with Anesthetic Agents
Pages 579-601
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