Non ci sono recensioni
History of Acute Promyelocytic Leukemia
Pages 1-16
This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and children, while highlighting the most recent therapeutic recommendations for relapsed disease and the evolving indications for autologous and allogeneic stem cell transplant. This volume also features chapters focusing on secondary APL and therapy, late effects, rare presentations such as APL in the elderly and during pregnancy, and rare APL variants that may represent therapeutic challenges.
Written by top experts in the field, Acute Promyelocytic Leukemia: A Clinical Guide is a valuable resource for clinicians and researchers who treat and investigate this disease in children and adults.
History of Acute Promyelocytic Leukemia
Pages 1-16
Molecular Targets of Treatment in APL
Pages 17-27
The Leukemic Stem Cell
Pages 29-40
Molecular Genetics of APL
Pages 41-53
APL Coagulopathy
Pages 55-70
Early Death in APL
Pages 71-86
Prognostic Factors in APL
Pages 87-98
First-Line Therapy for APL: Chemotherapy-Based Approach
Pages 99-112
First-Line Therapy: ATRA-ATO/Reduced Chemotherapy Approach
Pages 113-132
Cure of APL Without Chemotherapy
Pages 133-151
Minimal Residual Disease in APL
Pages 153-161
Treatment of Refractory and Relapsed APL
Pages 163-170
Hematopoietic Stem Cell Transplantation in APL
Pages 171-177
APL in Children
Pages 179-195
Management of APL in the Elderly
Pages 197-201
Special Situations in APL
Pages 203-210
APL in Developing Countries: A Chemotherapy-Based Approach
Pages 211-216
APL in Developing Countries: ATO-Based Approach
Pages 217-229
Therapy-Related Acute Promyelocytic Leukemia
Pages 231-242
Rare Acute Leukemia Variants Involving Retinoic Acid Receptor Genes
Pages 243-255
Management of Treatment-Related Complications in APL
Pages 257-267
Sei sicuro di voler eseguire questa azione?