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Sperm Chromatin: An Overview
Pages 3-30
Punto di Riferimento
per Medici e Operatori Sanitari
per Medici e Operatori Sanitari
LIBRERIA STUDIUM
A Clinician's Guide to Sperm DNA and Chromatin Damage
Zini, Agarwal
Editore
Springer
Anno
2018
Pagine
605
ISBN
9783319718149
214,00 €
DA SCONTARE
This comprehensive, up-to-date text, which brings together the key practical elements of the rapidly evolving field of sperm DNA and chromatin abnormalities, is divided thematically into five main sections. Part I discusses human sperm chromatin structure and nuclear architecture, while part II presents laboratory evaluation of sperm DNA damage, including SCSA, SCD, TUNEL and Comet assays, and cytochemical tests. Biological and clinical factors in the etiology of sperm DNA damage are discussed in part III, including oxidative stress, abortive apoptosis, cancer, and environmental and lifestyle factors. Part IV presents clinical studies on the utility of sperm DNA damage tests, both with natural and ART-assisted pregnancies, and debates the clinical utility of such tests. Finally, part V discusses current treatment options, such as antioxidant therapy, varicocelectomy, advanced sperm processing techniques and the use of testicular sperm.
We are now beginning to better understand the unique organization of the sperm chromatin, as well as the nature and etiology of sperm DNA damage. Written and edited by worldwide experts in andrology, A Clinician's Guide to Sperm DNA and Chromatin Damage is an excellent resource for reproductive medicine and REI specialists, urologists, reproductive biologists and any professional working with the infertile male.
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Sperm Nucleoproteins (Histones and Protamines)
Pages 31-51
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Sperm Nuclear Architecture
Pages 53-61
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Sperm Chromatin Structure Assay (SCSA®): Evolution from Origin to Clinical Utility
Pages 65-89
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TUNEL Assay
Pages 91-102
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TUNEL Assay by Benchtop Flow Cytometer in Clinical Laboratories
Pages 103-118
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The Comet Assay
Pages 119-135
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Sperm Chromatin Dispersion (SCD) Assay
Pages 137-152
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Cytochemical Tests of Sperm Chromatin Maturity
Pages 153-162
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Is There an Optimal Sperm DNA Test?
Pages 163-176
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Oxidative Stress
Pages 179-195
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Apoptosis in Ejaculated Spermatozoa and in the Normal and Pathological Testes: Abortive Apoptosis and Sperm Chromatin Damage
Pages 197-218
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Defective DNA Repair in Spermiogenesis
Pages 219-227
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Defective Spermatogenesis and Sperm DNA Damage
Pages 229-261
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Sperm Chromatin and Lifestyle Factors
Pages 263-279
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Cancer and Sperm DNA Damage
Pages 281-300
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Sperm Chromatin and Environmental Factors
Pages 301-319
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Sperm DNA Damage and Oocyte Repair Capability
Pages 321-346
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Experimental Studies on Sperm DNA Fragmentation and Reproductive Outcomes
Pages 349-363
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Sperm DNA and Natural Pregnancy
Pages 365-391
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Sperm DNA and ART (IUI, IVF, ICSI) Pregnancy
Pages 393-410
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Sperm DNA and Pregnancy Loss After IVF and ICSI
Pages 411-430
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Sperm DNA Tests Are Clinically Useful: Pro
Pages 431-467
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Sperm DNA Tests Are Clinically Useful: CON
Pages 469-476
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Antioxidant Therapy
Pages 479-493
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Varicocelectomy
Pages 495-512
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Physiological Intracytoplasmic Sperm Insemination Based on Hyaluronic Acid-Binding Ability
Pages 513-527
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Advanced Sperm Processing/Selection Techniques
Pages 529-543
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Use of Testicular Sperm for ICSI: Pro
Pages 545-557
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Debate on the Use of Testicular Sperm for ICSI: Con
Pages 559-570
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Strategies to Diminish DNA Damage in Sperm Samples Used for ART
Pages 571-587
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Sperm DNA Testing: Where Do We Go from Here?
Pages 589-593
